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peptides ACE-031

What is the ACE031?

ACE031 is intended for research purpose only. 
ACE031 should not be used for human consumption, diagnostic, therapeutic procedures, agricultural and 
veterinary purposes.

ACE031 is a soluble fusion protein that has been shown to increase muscle mass and strength in research 
studies.ACE031 is being studied as a treatment for metabolic diseases, renal neoplasms of childhood, 
cardiovascular anomalies, agerelated muscle loss, and cancer treatment related muscle loss and 
neuromuscular diseases.

ACE031 is a biologic therapeutic, based on activin receptor type IIB (ActRIIB). The molecule inhibits signalingvia the ActRIIB receptor binding and increase muscle mass and strength. ACE031 is a recombinant fusion protein that is artificially synthesized by 

fusion of standard antibody and a portion of ActRIIB receptor. 
The recombinant fusion protein eliminates myostatin and other biomolecules that limit muscle strength or growth.

"ACE-031 holds great potential as a treatment for patients suffering from neuromuscular diseases such as muscular dystrophy and amyotrophic lateral sclerosis (ALS)," said John Knopf, Ph.D., Chief Executive Officer of Acceleron. "We are moving forward with great confidence and excitement with the ACE-031 program as well as our overall muscle franchise."
 
Muscle is increasingly recognized as central to many biological processes and plays a major role in human health. The loss of muscle mass and strength is ultimately directly related to the cause of death in neuromuscular diseases such as muscular dystrophy and amyotrophic lateral sclerosis. Severe muscle loss in cancer leads to serious complications and a poor prognosis. Muscle loss is a natural consequence of aging, similar to bone loss, resulting in decreased muscle strength (frailty), reduced mobility and an increased risk of a fall and broken bones. In metabolic diseases, an imbalance of diet, energy utilization and skeletal muscle leads to poor metabolic function. By increasing muscle mass there is a corresponding decrease in fat mass and improvements in metabolic function.